Endocrine Abstracts

IntroductionCurrent rise in use of monoclonal antibodies to Immune Check Point inhibitors (ICPIs) has led to the appearance of a great variety of immune-related adverse effects (irAEs), mainly affecting gastrointestinal tract, skin, liver and endocrinological system. With a variable prevalence (4–21%), thyroid dysfunction (TD) is the most common immune-mediated endocrinopathy. However, in the literature, it occurs in different patterns and levels of...

It is well established that thyroid hormones (TH) possess the ability to regulate body temperature. Thermogenesis can be induced peripherally in fat and muscle, but the active hormone T3 can also act centrally in the brain to raise the body temperature via the sympathetic nervous system. In recent studies, T3 treatment in mice has been shown to elevate the body temperature even far below thermoneutrality. This indicates that the induced hyperthyroidism causes a state of pyrexi...

Alemtuzumab is a monoclonal antibody used in the treatment of relapsing-remitting multiple sclerosis (RRMS). Thyroid dysfunction is a common side effect. Alemtuzumab induced Graves’ disease (AIGD) is notable for its fluctuating and unpredictable course. We present the case of two women with RRMS who required total thyroidectomy to manage AIGD and were followed up in our antenatal endocrine clinic during their pregnancy. The first patient is a 31-year-old lady who develope...

Background: SEREN is an established, QISMET accredited structured education programme for children/young people (CYP) and their families with Type 1 diabetes mellitus (T1DM), developed in Wales. The first module ‘Diabetes at diagnosis’ has been in use in Wales since 2016. The resources and health care professional (HCP) training have also been used by some paediatric diabetes teams in England who have since embedded SEREN into their diabetes care. Th...

Background and Objectives: The differential diagnosis between arginine vasopressin (AVP) deficiency (AVP-D, formerly known as central diabetes insipidus) and primary polydipsia (PP) remains challenging. To date, the method with the highest diagnostic accuracy is osmotically-stimulated copeptin – a surrogate marker of AVP – using hypertonic saline infusion. However, this method is often limited to experienced hospitals, requires close monitoring, and may be cumbersome...

Background: Adamantinomatous craniopharyngioma (CP) is a rare embryonal malformation originating from remnants of the craniopharyngeal duct and located in the sellar and/or parasellar area. Overall survival rates are high (92%), but frequently quality of life (QoL) is severely impaired in patients with CP involving hypothalamic structures. Tumor- and/or treatment-related hypothalamic lesions result in disturbances of circadian rhythms including increased daytime sleepiness.</p...

Objective: Menopausal hormone therapy (MHT) is efficacious in reducing the risk of vertebral, non-vertebral and hip fractures, irrespective of age, falls risk or baseline FRAX probability. However, the optimal sequential anti-osteoporotic treatment after MHT discontinuation has not yet been designated. This systematic review aimed to obtain the best evidence regarding the effect of antiresorptive or osteoanabolic treatment on bone mineral density (BMD) and/or fracture risk fol...

Roux-en-Y gastric bypass (RYGB) surgery results in rapid weight loss, reduced adiposity and improved overall metabolism. These health benefits cannot solely be attributed to the reduced caloric intake, but the exact mechanisms are still incompletely understood. Several studies in rodents and humans demonstrated alterations of the gut microbiota following RYGB, suggesting a crucial role of the host-microbial interactions for the beneficial effects of surgery. This study aimed t...

We present a case of a young female, who was diagnosed with Graves’ thyrotoxicosis in 2019 with very high TSH Receptor antibody. She had a goitre and mild thyroid ophthalmopathy and was commenced on carbimazole. She was followed up in the Endocrine Clinic and carbimazole was titrated according to the clinical and biochemical picture. Her past medical history included epilepsy, generalised anxiety, and emotionally unstable personality disorder. She had difficult social cir...

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of patients in a secondary referral hospital and their glycemic control expressed as FGM targets.Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 referred to a secondary care center in Montilla (Córdoba).Results: 101 patients included. Mean a...